Geneva, Switzerland – The World Health Organization (WHO) has reaffirmed that there is no conclusive scientific evidence linking the use of paracetamol (acetaminophen) during pregnancy to autism spectrum disorder (ASD).
In a statement issued on September 24, 2025, WHO emphasized that autism remains a complex neurodevelopmental condition shaped by multiple factors, including genetics and environmental influences, but no single cause has been identified.
“Extensive research has been undertaken over the past decade, including large-scale studies, looking into links between acetaminophen use during pregnancy and autism. At this time, no consistent association has been established,” WHO said.
Autism spectrum disorder, which affects how individuals communicate, interact, and perceive the world, impacts an estimated 62 million people globally, about 1 in 127. While awareness and diagnosis have improved, WHO noted that the condition’s origins remain poorly understood.
The health body advised expectant mothers to seek professional medical guidance when using any medication. “Any medicine should be used with caution during pregnancy, especially in the first three months, and in line with advice from health professionals,” WHO stressed.
WHO also reiterated that childhood vaccines do not cause autism, citing decades of robust research. “Large, high-quality studies from many countries have all reached the same conclusion. Original studies suggesting a link were flawed and have been discredited,” it stated.
Independent experts advising the WHO since 1999 have consistently confirmed that vaccines, including those containing thiomersal or aluminum, are safe. Immunization schedules, the agency added, have saved at least 154 million lives over the past 50 years and now protect against 30 infectious diseases.
Delaying or disrupting vaccination, WHO warned, puts children and vulnerable populations at risk, particularly infants too young to be immunized and people with weakened immune systems.
Autism and other neurodevelopmental disorders will feature prominently at the 4th UN High-Level Meeting on Noncommunicable Diseases and Mental Health set for September 25. WHO said it remains committed to partnering with autistic-led organizations and advocacy groups to advance research, strengthen services, and tackle stigma.
“As a global community, we need to do more to understand the causes of autism and how best to care for and support the needs of autistic people and their families,” the statement concluded.
